Abstract
Ketoacidotic coma is one of the possible diabetes mellitus first symptoms. It results from complete or relative lack of insuline and is often associated with type 1 diabetes. The authors report a case of a 45-years old woman with inaugural diabetes of which atypical features have motivated the study of MODY gene (maturity-onset diabetes of the young). Gly574ser polymorphism in the HNF-1alpha gene was found, in homozygous state, and the question of the responsibility of this polymorphism in this diabete is asked.
Publication types
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Case Reports
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Comparative Study
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English Abstract
MeSH terms
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Diabetes Mellitus, Type 1 / diagnosis
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Diabetes Mellitus, Type 1 / genetics
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Diabetes Mellitus, Type 2 / diagnosis
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Diabetes Mellitus, Type 2 / genetics
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Diabetic Coma*
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Diabetic Ketoacidosis* / diagnosis
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Diabetic Ketoacidosis* / genetics
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Diagnosis, Differential
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Fatal Outcome
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Female
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Glycine / genetics
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Hepatocyte Nuclear Factor 1-alpha* / genetics
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Hepatocyte Nuclear Factor 4 / genetics
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Humans
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Middle Aged
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Mutation
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Polymorphism, Genetic
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Prognosis
Substances
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HNF1A protein, human
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HNF4A protein, human
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Hepatocyte Nuclear Factor 1-alpha
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Hepatocyte Nuclear Factor 4
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Glycine