Abstract
Linezolid resistance has dominantly been mediated by mutations in 23S rRNA or ribosomal protein L4 genes. Recently, cfr has demonstrated the ability to produce a phenotype of resistance to not only oxazolidinones, but also other antimicrobial classes (phenicols, lincosamides, pleuromutilins, and streptogramin A). We describe the first detection of cfr-mediated linezolid resistance in Staphylococcus aureus and Staphylococcus epidermidis recovered from human infection cases monitored during the 2007 LEADER Program.
MeSH terms
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Acetamides / pharmacology*
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Anti-Bacterial Agents / pharmacology
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Anti-Infective Agents / pharmacology*
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism
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Drug Resistance, Bacterial / genetics*
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Humans
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Linezolid
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Methyltransferases / genetics*
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Methyltransferases / metabolism
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Oxazolidinones / pharmacology*
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Sequence Analysis, DNA
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Staphylococcal Infections / microbiology
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / enzymology
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Staphylococcus aureus / genetics
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Staphylococcus epidermidis / drug effects*
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Staphylococcus epidermidis / enzymology
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Staphylococcus epidermidis / genetics
Substances
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Acetamides
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Anti-Bacterial Agents
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Anti-Infective Agents
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Bacterial Proteins
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Oxazolidinones
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Methyltransferases
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Linezolid