Direct synthesis of hierarchical monolithic silica for high performance liquid chromatography

J Chromatogr A. 2008 May 9;1190(1-2):232-40. doi: 10.1016/j.chroma.2008.03.045. Epub 2008 Mar 21.

Abstract

The silica-based monolith exhibiting a hierarchical bimodal porous structure has been directly synthesized via lytropic mesophase. The hydrolysis and condensation of tetramethoxysilane (TMOS) in the presence of poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide) (P123) and acetic acid results in silica monolith with MSU-type mesoporous structure embedded in the skeleton of the interconnected macropore. The silica monolith with bimodal porous structure can separate benzene and phenol with high flow rate and low back-pressure. Moreover, the chromatographic property of C18-grafted silica monolith is investigated in the separation of aromatic molecules. Our primary result shows that the silica monolith with interconnected macropore and MSU-type mesopore is a promising packing material as stationary phase for high performance liquid chromatography.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromatography, High Pressure Liquid / methods*
  • Microscopy, Electron, Scanning
  • Microscopy, Electron, Transmission
  • Silicon Dioxide / chemical synthesis*

Substances

  • Silicon Dioxide