Expression of three serine protease genes from the South East Asian malaria vector, Anopheles dirus, in relation to blood feeding and parasite infection

Patchara Sriwichai; Yupha Rongsriyam; Narissara Jariyapan; Chamnarn Apiwathnasorn; Jetsumon Sattabongkot; Susan Paskewitz

doi:10.1016/j.dci.2008.02.010

Expression of three serine protease genes from the South East Asian malaria vector, Anopheles dirus, in relation to blood feeding and parasite infection

Dev Comp Immunol. 2008;32(9):1011-4. doi: 10.1016/j.dci.2008.02.010. Epub 2008 Mar 25.

Authors

Patchara Sriwichai¹, Yupha Rongsriyam, Narissara Jariyapan, Chamnarn Apiwathnasorn, Jetsumon Sattabongkot, Susan Paskewitz

Affiliation

¹ Department of Medical Entomology, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.

PMID: 18395797
DOI: 10.1016/j.dci.2008.02.010

Abstract

Three serine protease cDNA clones were isolated from Anopheles dirus, a major vector of malaria in Southeast Asia. Transcript abundance was examined following infection by Plasmodium falciparum by RT-PCR analysis. SerF3 exhibited increased transcript abundance in the whole body at 10 days post-infection with P. falciparum. All three genes are candidates for further investigation to determine their roles in mosquito immune responses.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anopheles / enzymology
Anopheles / genetics*
Anopheles / parasitology*
Base Sequence
Blood
Feeding Behavior
Gene Expression
Genes, Insect*
Malaria, Falciparum / parasitology
Malaria, Falciparum / transmission
Molecular Sequence Data
Plasmodium falciparum / physiology*
Serine Endopeptidases / genetics*

Substances

Serine Endopeptidases

Associated data

GENBANK/DQ465367
GENBANK/EF492430
GENBANK/EF492431

Grants and funding

R01 AI046031/AI/NIAID NIH HHS/United States