A clinical and histopathologic study of granulomatous rosacea

J Am Acad Dermatol. 1991 Dec;25(6 Pt 1):1038-43. doi: 10.1016/0190-9622(91)70304-k.

Abstract

A retrospective clinical and histopathologic study of 53 patients with granulomatous rosacea was undertaken. The patients had a broad clinical spectrum of lesions that ranged from primarily erythema to papulonodular lesions. Extrafacial lesions occurred in 15% of patients. Histologic examination showed mixed lymphohistiocytic inflammation (primarily lymphocytic inflammation in 40% of patients and primarily histiocytic with a few giant cells in 34%), epithelioid granulomas in 11% of patients, and epithelioid granulomas with caseation necrosis in 11%. Most patients had a good response to oral antibiotic therapy. Granulomatous rosacea is not a distinct disease but can be regarded and treated as a subtype of rosacea.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Blister / pathology
  • Elastic Tissue / pathology
  • Erythema / pathology
  • Female
  • Folliculitis / pathology
  • Granuloma / drug therapy
  • Granuloma / pathology
  • Histiocytes / pathology
  • Humans
  • Lymphocytes / pathology
  • Male
  • Middle Aged
  • Retrospective Studies
  • Rosacea / drug therapy
  • Rosacea / pathology*
  • Single-Blind Method
  • Skin / blood supply
  • Skin / pathology
  • Skin Aging / pathology
  • Telangiectasis / pathology