Abstract
The interaction between Cu(II) and the rat amyloid beta (1-28) fragment in micellar solutions at pH 7.5 was investigated by CD and NMR spectroscopy; the proton-copper distances were used in restrained molecular dynamics simulations to obtain a structural model of the Cu(II) complex.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Amyloid beta-Peptides / chemistry*
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Animals
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Binding Sites
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Copper / chemistry*
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Hydrogen-Ion Concentration
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Models, Molecular
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Molecular Sequence Data
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Peptide Fragments / chemistry*
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Protein Structure, Secondary
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Rats
Substances
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Amyloid beta-Peptides
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Peptide Fragments
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amyloid beta-protein (1-28)
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Copper