Abstract
Two lines of investigation support a new hypothesis concerning the role of protein synthesis in the mitogenic pathway. The first is that a variety of mitogens and oncogene products increase phosphorylation and thereby activate eIF-4E, which is involved in the rate-limiting transfer of mRNA to ribosomes. The second is that overexpression or microinjection of eIF-4E induce rapid cell proliferation and oncogenic transformation.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Cell Division / physiology*
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Cell Transformation, Neoplastic / metabolism*
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Eukaryotic Initiation Factor-4E
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Mitogens
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Oncogene Proteins
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Peptide Initiation Factors / metabolism
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Phosphorylation
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Protein Biosynthesis*
Substances
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Eukaryotic Initiation Factor-4E
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Mitogens
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Oncogene Proteins
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Peptide Initiation Factors