Isolation of Bacillus stearothermophilus constituent that suppresses mouse mixed leukocyte reaction in vitro

Y Kohama; N Murayama; K Tanaka; A Inada; T Nakanishi; M Itoh; X Ying; T Mimura

doi:10.1248/cpb.39.3378

Isolation of Bacillus stearothermophilus constituent that suppresses mouse mixed leukocyte reaction in vitro

Chem Pharm Bull (Tokyo). 1991 Dec;39(12):3378-80. doi: 10.1248/cpb.39.3378.

Authors

Y Kohama¹, N Murayama, K Tanaka, A Inada, T Nakanishi, M Itoh, X Ying, T Mimura

Affiliation

¹ Faculty of Pharmaceutical Sciences, Osaka University, Japan.

PMID: 1839973
DOI: 10.1248/cpb.39.3378

Abstract

A novel immunosuppressant, Fr.5-B, has been isolated from the debris of Bacillus stearothermophilus UK563 autolysate. Fr.5-B suppressed mouse mixed leukocyte reaction at doses ranging from 10(-4) to 1 microgram/ml, but not proliferation stimulated by concanavalin A and lipopolysaccharide.

MeSH terms

Animals
Concanavalin A / pharmacology
Geobacillus stearothermophilus / chemistry*
Immunosuppressive Agents / isolation & purification*
Lipopolysaccharides / isolation & purification
Lymphocyte Culture Test, Mixed*
Male
Mice
Mice, Inbred BALB C

Substances

Immunosuppressive Agents
Lipopolysaccharides
Concanavalin A