Successful treatment of disseminated Geotrichum capitatum infection with a combination of caspofungin and voriconazole in an immunocompromised patient

Mycoses. 2008 May;51(3):270-2. doi: 10.1111/j.1439-0507.2007.01484.x.

Abstract

Disseminated Geotrichum capitatum infection is uncommon, and has been reported exclusively in immunocompromised patients. The prognosis is poor with a mortality rate of approximately 50-75%. We report a case of disseminated G. capitatum infection in a severely neutropenic patient who was receiving chemotherapy for acute myeloblastic leukaemia. G. capitatum was isolated from blood cultures, skin lesions, bronchoalveolar lavage fluid, throat swabs and stools. The infection was successfully cured with a combination of voriconazole and caspofungin.

Publication types

  • Letter

MeSH terms

  • Antifungal Agents / therapeutic use
  • Caspofungin
  • Drug Combinations
  • Echinocandins / therapeutic use*
  • Geotrichosis / diagnosis
  • Geotrichosis / drug therapy*
  • Geotrichosis / immunology
  • Geotrichum / isolation & purification*
  • Humans
  • Immunocompromised Host*
  • Lipopeptides
  • Male
  • Middle Aged
  • Pyrimidines / therapeutic use*
  • Triazoles / therapeutic use*
  • Voriconazole

Substances

  • Antifungal Agents
  • Drug Combinations
  • Echinocandins
  • Lipopeptides
  • Pyrimidines
  • Triazoles
  • Caspofungin
  • Voriconazole