Design, synthesis and evaluation of 2-phenyl-1H-benzo[d]imidazole-4,7-diones as vascular smooth muscle cell proliferation inhibitors

Chung-Kyu Ryu; Ra-Young Lee; Seung-Yon Lee; Hwa-Jin Chung; Sang Kook Lee; Kwang-Hoe Chung

doi:10.1016/j.bmcl.2008.03.066

Design, synthesis and evaluation of 2-phenyl-1H-benzo[d]imidazole-4,7-diones as vascular smooth muscle cell proliferation inhibitors

Bioorg Med Chem Lett. 2008 May 1;18(9):2948-51. doi: 10.1016/j.bmcl.2008.03.066. Epub 2008 Mar 27.

Authors

Chung-Kyu Ryu¹, Ra-Young Lee, Seung-Yon Lee, Hwa-Jin Chung, Sang Kook Lee, Kwang-Hoe Chung

Affiliation

¹ College of Pharmacy, Ewha Womans University, Seodaemun-ku, Seoul 120-750, Republic of Korea. [email protected]

PMID: 18400498
DOI: 10.1016/j.bmcl.2008.03.066

Abstract

A series of 2-phenyl-1H-benzo[d]imidazole-4,7-diones were synthesized and tested for their inhibitory activity on the PDGF-stimulated proliferation of rat aortic vascular smooth muscle cells. Among the tested compounds, 6-arylthio-5-chloro-2-phenyl-1H-benzo[d]imidazole-4,7-diones exhibited an potent antiproliferative activity.

Publication types

Evaluation Study
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Aorta / cytology
Aorta / drug effects*
Benzimidazoles / chemical synthesis
Benzimidazoles / pharmacology*
Cell Proliferation / drug effects*
Cells, Cultured
Drug Design*
Growth Inhibitors / chemical synthesis
Growth Inhibitors / pharmacology*
Inhibitory Concentration 50
Mitogen-Activated Protein Kinases / metabolism
Models, Chemical
Muscle, Smooth, Vascular / cytology
Muscle, Smooth, Vascular / drug effects*
Platelet-Derived Growth Factor / metabolism
Rats
Structure-Activity Relationship

Substances

Benzimidazoles
Growth Inhibitors
Platelet-Derived Growth Factor
Mitogen-Activated Protein Kinases