Nucleophosmin (NPM1) mutations in acute myeloid leukemia: an ongoing (cytoplasmic) tale of dueling mutations and duality of molecular genetic testing methodologies

Gerald Wertheim; Adam Bagg

doi:10.2353/jmoldx.2008.080019

Nucleophosmin (NPM1) mutations in acute myeloid leukemia: an ongoing (cytoplasmic) tale of dueling mutations and duality of molecular genetic testing methodologies

J Mol Diagn. 2008 May;10(3):198-202. doi: 10.2353/jmoldx.2008.080019. Epub 2008 Apr 10.

Authors

Gerald Wertheim¹, Adam Bagg

Affiliation

¹ Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104-4283, USA.

Abstract

This Commentary highlights two articles that focus on molecular techniques to identify mutations in nucleophosmin (NPM1), which is the most frequently mutated gene in cytogenetically normal acute myeloid leukemia (CN-AML)

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Humans
Leukemia, Myeloid, Acute / diagnosis*
Leukemia, Myeloid, Acute / genetics*
Leukemia, Myeloid, Acute / metabolism
Molecular Biology*
Molecular Diagnostic Techniques*
Mutation*
Nuclear Proteins / genetics*
Nuclear Proteins / metabolism
Nucleophosmin
Prognosis

Substances

NPM1 protein, human
Nuclear Proteins
Nucleophosmin