Abstract
The present study examined the levels of Angiotensin II type 1 receptor (AT(1)) and type 2 receptor (AT(2)) in the brain stem and cerebral cortex of the stroke-prone spontaneously hypertensive rat (SHR-sp) after long-term treatment with three types of antihypertensive drugs: valsartan, enalapril, and amlodipine. In both tissues, expression of the AT(1) was decreased by administration of each drug. Expression of the AT(2) was decreased in the cerebral cortex by drug administration, but did not change in the brain stem. This study may contribute to elucidating the relationship between AT(1) and AT(2) expressions and the effect of antihypertensive drugs in SHR-sp brain.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amlodipine / pharmacology
-
Angiotensin II Type 1 Receptor Blockers / pharmacology
-
Angiotensin-Converting Enzyme Inhibitors / pharmacology
-
Animals
-
Antihypertensive Agents / pharmacology*
-
Blood Pressure / drug effects
-
Brain Stem / drug effects*
-
Brain Stem / metabolism
-
Calcium Channel Blockers / pharmacology
-
Cerebral Cortex / drug effects*
-
Cerebral Cortex / metabolism
-
Disease Models, Animal
-
Down-Regulation
-
Enalapril / pharmacology
-
Hypertension / complications
-
Hypertension / drug therapy*
-
Hypertension / metabolism
-
Hypertension / physiopathology
-
Male
-
RNA, Messenger / metabolism
-
Rats
-
Rats, Inbred SHR
-
Receptor, Angiotensin, Type 1 / drug effects*
-
Receptor, Angiotensin, Type 1 / genetics
-
Receptor, Angiotensin, Type 1 / metabolism
-
Receptor, Angiotensin, Type 2 / drug effects*
-
Receptor, Angiotensin, Type 2 / genetics
-
Receptor, Angiotensin, Type 2 / metabolism
-
Stroke / etiology
-
Stroke / metabolism
-
Stroke / physiopathology
-
Stroke / prevention & control*
-
Tetrazoles / pharmacology
-
Time Factors
-
Valine / analogs & derivatives
-
Valine / pharmacology
-
Valsartan
Substances
-
Angiotensin II Type 1 Receptor Blockers
-
Angiotensin-Converting Enzyme Inhibitors
-
Antihypertensive Agents
-
Calcium Channel Blockers
-
RNA, Messenger
-
Receptor, Angiotensin, Type 1
-
Receptor, Angiotensin, Type 2
-
Tetrazoles
-
Amlodipine
-
Enalapril
-
Valsartan
-
Valine