Giant hepatic adenoma with atypical features in a patient on oxcarbazepine therapy

T B Lautz; M J Finegold; A C Chin; R A Superina

doi:10.1016/j.jpedsurg.2007.11.036

Giant hepatic adenoma with atypical features in a patient on oxcarbazepine therapy

J Pediatr Surg. 2008 Apr;43(4):751-4. doi: 10.1016/j.jpedsurg.2007.11.036.

Authors

T B Lautz¹, M J Finegold, A C Chin, R A Superina

Affiliation

¹ Department of Surgery, Children's Memorial Hospital, Feinberg School of Medicine of Northwestern University, Chicago, IL 60614, USA.

PMID: 18405728
DOI: 10.1016/j.jpedsurg.2007.11.036

Abstract

An association between oxcarbazepine therapy and hepatic adenoma (HA) has been documented in animal models but not observed in humans. The authors report a case of a 16-year-old girl on oxcarbazepine therapy for seizure disorder who presented with a giant HA. Pathology of the HA was notable for marked periductal fibrosis and glycoprotein inclusions in the nontumor liver. The patient was not on oral contraceptives and has no other known risk factors for HA.

Publication types

Case Reports

MeSH terms

Adenoma, Liver Cell / chemically induced*
Adenoma, Liver Cell / pathology
Adenoma, Liver Cell / surgery
Adolescent
Anticonvulsants / adverse effects*
Biopsy
Carbamazepine / adverse effects
Carbamazepine / analogs & derivatives*
Female
Humans
Liver Neoplasms / chemically induced*
Liver Neoplasms / pathology
Liver Neoplasms / surgery
Oxcarbazepine
Seizures / drug therapy
Treatment Outcome

Substances

Anticonvulsants
Carbamazepine
Oxcarbazepine