Role of differential expression of streptococcal arginine deiminase in inhibition of fimA expression in Porphyromonas gingivalis

J Bacteriol. 2008 Jun;190(12):4367-71. doi: 10.1128/JB.01898-07. Epub 2008 Apr 11.

Abstract

Streptococcus cristatus ArcA inhibits production of a major adhesin, FimA, in Porphyromonas gingivalis, a primary periodontal pathogen. In this study, we demonstrate the differential expression of arcA in two streptococcal species. The expression level of arcA in streptococci appears to be controlled by both cis and trans elements.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Base Sequence
  • Blotting, Western
  • Fimbriae Proteins / genetics
  • Fimbriae Proteins / metabolism
  • Gene Expression Regulation, Bacterial
  • Hydrolases / genetics
  • Hydrolases / metabolism*
  • Molecular Sequence Data
  • Porphyromonas gingivalis / genetics
  • Porphyromonas gingivalis / metabolism*
  • Streptococcus / enzymology*
  • Streptococcus / genetics

Substances

  • Bacterial Proteins
  • Fimbriae Proteins
  • Hydrolases
  • arginine deiminase