Abstract
In this study, the use of isothermal microcalorimetry (IMC) for differentiation between methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) and MIC determination was evaluated. It was possible to differentiate between MRSA and MSSA within 4 h, whereas the standard method required 24 h. The MICs of cefoxitin were successfully determined for MRSA and MSSA by using IMC.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Calorimetry / instrumentation
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Calorimetry / methods*
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Cefoxitin / pharmacology
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Hot Temperature
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Humans
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Methicillin / pharmacology*
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Methicillin Resistance*
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Microbial Sensitivity Tests / methods
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Staphylococcal Infections / microbiology
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Staphylococcus aureus / classification*
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / isolation & purification
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Time Factors
Substances
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Anti-Bacterial Agents
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Cefoxitin
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Methicillin