Solitary fibrous tumour of the liver with IGF-II-related hypoglycaemia. A case report

F Famà; Yves Le Bouc; G Barrande; A Villeneuve; M G Berry; R R Pidoto; O Saint Marc

doi:10.1007/s00423-008-0329-z

Solitary fibrous tumour of the liver with IGF-II-related hypoglycaemia. A case report

Langenbecks Arch Surg. 2008 Jul;393(4):611-6. doi: 10.1007/s00423-008-0329-z. Epub 2008 Apr 17.

Authors

F Famà¹, Yves Le Bouc, G Barrande, A Villeneuve, M G Berry, R R Pidoto, O Saint Marc

Affiliation

¹ Department of Human Pathology, University Hospital of Messina, Messina, Italy. [email protected]

PMID: 18418627
DOI: 10.1007/s00423-008-0329-z

Abstract

Introduction: We report a rare case of solitary fibrous tumour (SFT) of the liver associated with non-islet cell tumour hypoglycaemia (NICTH), which caused a hypoglycaemic coma due to over-production of big-insulin-like growth factor-II.

Discussion: Although generally benign, SFTs are better characterised, lately due to Western blot, but less than 40 cases have been reported where the liver is the target organ. In only two benign cases has hypoglycaemia been a feature.

Conclusion: We report for the first time a demonstrable relationship between benign liver SFT and NICTH.

Publication types

Case Reports

MeSH terms

Aged
Coma / blood
Coma / etiology*
Diagnosis, Differential
Hepatectomy
Humans
Hypoglycemia / blood
Hypoglycemia / etiology*
Insulin-Like Growth Factor II / metabolism*
Liver / pathology
Liver Neoplasms / blood
Liver Neoplasms / complications*
Liver Neoplasms / diagnostic imaging
Liver Neoplasms / pathology
Liver Neoplasms / surgery
Male
Paraneoplastic Syndromes / blood
Paraneoplastic Syndromes / etiology*
Protein Precursors / blood*
Solitary Fibrous Tumors / blood
Solitary Fibrous Tumors / complications*
Solitary Fibrous Tumors / diagnostic imaging
Solitary Fibrous Tumors / pathology
Solitary Fibrous Tumors / surgery
Tomography, Spiral Computed

Substances

Protein Precursors
proinsulin-like growth factor II
Insulin-Like Growth Factor II