Invasive pulmonary infection due to Trichoderma longibrachiatum mimicking invasive Aspergillosis in a neutropenic patient successfully treated with voriconazole combined with caspofungin

Clin Infect Dis. 2008 May 15;46(10):e116-8. doi: 10.1086/587750.

Abstract

Trichoderma longibrachiatum, a filamentous fungus, was recently described as an emerging pathogen in immunocompromised patients. Here, we report the first case, to our knowledge, of isolated invasive lung infection by T. longibrachiatum in a patient with hematologic malignancy. The infection mimicked invasive pulmonary aspergillosis and was successfully treated with a combination of voriconazole and caspofungin.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antifungal Agents / therapeutic use*
  • Caspofungin
  • Diagnosis, Differential
  • Drug Therapy, Combination
  • Echinocandins / therapeutic use*
  • Hematologic Neoplasms / complications
  • Humans
  • Lipopeptides
  • Male
  • Mycoses / diagnosis*
  • Mycoses / drug therapy
  • Neutropenia / complications*
  • Pneumonia / drug therapy
  • Pneumonia / microbiology*
  • Pyrimidines / therapeutic use*
  • Radiography, Thoracic
  • Tomography, X-Ray Computed
  • Triazoles / therapeutic use*
  • Trichoderma / isolation & purification*
  • Voriconazole

Substances

  • Antifungal Agents
  • Echinocandins
  • Lipopeptides
  • Pyrimidines
  • Triazoles
  • Caspofungin
  • Voriconazole