Nonpeptidic vinyl and allyl phosphonates as falcipain-2 inhibitors

ChemMedChem. 2008 Jul;3(7):1030-3. doi: 10.1002/cmdc.200800050.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Benzodiazepines / chemistry
  • Cysteine Endopeptidases / drug effects*
  • Cysteine Endopeptidases / metabolism
  • Cysteine Proteinase Inhibitors / chemical synthesis
  • Cysteine Proteinase Inhibitors / pharmacology*
  • Models, Chemical
  • Organophosphonates / chemical synthesis
  • Organophosphonates / pharmacology*
  • Plasmodium falciparum / drug effects*
  • Plasmodium falciparum / growth & development
  • Structure-Activity Relationship
  • Sulfones / chemical synthesis
  • Sulfones / pharmacology*

Substances

  • Cysteine Proteinase Inhibitors
  • Organophosphonates
  • Sulfones
  • Benzodiazepines
  • divinyl sulfone
  • Cysteine Endopeptidases
  • falcipain 2