A murine model of retroviral encephalopathy

Curr Protoc Neurosci. 2002 Feb:Chapter 9:Unit9.8. doi: 10.1002/0471142301.ns0908s17.

Abstract

This unit delineates the steps for production of a murine model of retroviral encephalopathy. The LP-BM5 infected mouse develops a chronic inflammation of the brain secondary to profound immune deficiency. The model is robust, develops rapidly and does not require the use of human pathogens. In addition, the behavioral and neurochemical characteristics of this model is reviewed.

Publication types

  • Review

MeSH terms

  • Animals
  • Disease Models, Animal*
  • Encephalitis, Viral / immunology
  • Encephalitis, Viral / pathology
  • Encephalitis, Viral / virology*
  • Leukemia Virus, Murine* / immunology
  • Leukemia Virus, Murine* / isolation & purification
  • Leukemia Virus, Murine* / pathogenicity
  • Leukemia, Experimental* / immunology
  • Leukemia, Experimental* / pathology
  • Leukemia, Experimental* / virology
  • Mice
  • Mice, Inbred C57BL
  • Tumor Virus Infections* / immunology
  • Tumor Virus Infections* / pathology
  • Tumor Virus Infections* / virology