Abstract
Tardive laryngeal dystonia, a rare form of dystonic syndrome, was only reported to be induced by typical antipsychotics. Here, we report one case of ziprasidone-induced tardive laryngeal dystonia in a schizophrenic female patient, who showed dysphonia, hoarseness and dyspnea after taking ziprasidone 120 mg/day for 8 months. These symptoms were significantly improved after discontinuing ziprasidone and increasing the dose of trihexyphenidyl for 1 week. Although atypical antipsychotics are associated with a lower risk of extrapyramidal symptoms, caution should be taken for any tardive dystonic movement when using these medications.
MeSH terms
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Adult
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Antiparkinson Agents / therapeutic use
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Antipsychotic Agents / adverse effects*
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Antipsychotic Agents / therapeutic use
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Dose-Response Relationship, Drug
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Drug Therapy, Combination
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Dyspnea / chemically induced
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Dyspnea / diagnosis
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Dystonia / chemically induced*
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Dystonia / diagnosis
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Female
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Hoarseness / chemically induced
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Hoarseness / diagnosis
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Humans
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Laryngeal Diseases / chemically induced*
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Laryngeal Diseases / diagnosis
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Piperazines / adverse effects*
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Piperazines / therapeutic use
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Schizophrenia, Paranoid / drug therapy*
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Thiazoles / adverse effects*
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Thiazoles / therapeutic use
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Trihexyphenidyl / therapeutic use
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Voice Disorders / chemically induced
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Voice Disorders / diagnosis
Substances
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Antiparkinson Agents
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Antipsychotic Agents
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Piperazines
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Thiazoles
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Trihexyphenidyl
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ziprasidone