In London, Ontario, the 8th Annual Joint meeting of the Great Lakes GPCR Retreat and the Club des Récepteurs à Sept Domaines Transmembranaires (now known simply as the GPCR Retreat) was held September 27-29, 2007. This meeting gathers together a core group of investigators from Michigan, Ontario, and Québec and has steadily increased its attendance in both the eastern (Europe) and western (USA, Canada) directions. The highlight this year was a sneak preview of the beta(2)AR crystal structure provided by Brian Kobilka, but as can be seen below, many other cutting edge talks were heard as well.