Application of the superarmed glycosyl donor to chemoselective oligosaccharide synthesis

Org Lett. 2008 Jun 5;10(11):2107-10. doi: 10.1021/ol800648d. Epub 2008 May 1.

Abstract

Recently, we discovered a novel method for "superarming" glycosyl donors. Herein, this concept has been exemplified in one-pot oligosaccharide syntheses, whereby the superarmed glycosyl donor was chemoselectively activated over traditional "armed" and disarmed glycosyl acceptors. Direct side-by-side comparison of the reactivities of the classic armed and superarmed glycosyl donors further validates the credibility of the novel concept.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Glycosides / chemistry*
  • Glycosylation
  • Oligosaccharides / chemical synthesis*
  • Oligosaccharides / chemistry
  • Substrate Specificity

Substances

  • Glycosides
  • Oligosaccharides