Abstract
Two new dimeric bromopyrrole alkaloids, nagelamides K (1) and L (2), have been isolated from Okinawan marine sponges Agelas species, and the structures and stereochemistry were elucidated from spectroscopic data. Nagelamide K (1) is a bromopyrrole alkaloid possessing a rare piperidinoiminoimidazolone ring with an aminoimidazole ring and a taurine unit, while nagelamide L (2) is a unique dimeric bromopyrrole alkaloid containing an ester linkage. Nagelamides K (1) and L (2) exhibited antimicrobial activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Agelas / chemistry*
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Alkaloids / chemical synthesis
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Alkaloids / chemistry*
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Alkaloids / pharmacology*
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Animals
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Anti-Infective Agents / chemical synthesis
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Anti-Infective Agents / chemistry*
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Anti-Infective Agents / pharmacology*
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Dimerization
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Micrococcus luteus / drug effects
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Pyrroles / chemical synthesis
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Pyrroles / chemistry*
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Pyrroles / pharmacology*
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Stereoisomerism
Substances
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Alkaloids
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Anti-Infective Agents
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Pyrroles
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nagelamide K
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nagelamide L