Posaconazole enhances the activity of amphotericin B against hyphae of zygomycetes in vitro

Susanne Perkhofer; Maria Locher; Manuel Cuenca-Estrella; Reinhard Rüchel; Reinhard Würzner; Manfred P Dierich; Cornelia Lass-Flörl

doi:10.1128/AAC.00492-08

Posaconazole enhances the activity of amphotericin B against hyphae of zygomycetes in vitro

Antimicrob Agents Chemother. 2008 Jul;52(7):2636-8. doi: 10.1128/AAC.00492-08. Epub 2008 May 5.

Authors

Susanne Perkhofer¹, Maria Locher, Manuel Cuenca-Estrella, Reinhard Rüchel, Reinhard Würzner, Manfred P Dierich, Cornelia Lass-Flörl

Affiliation

¹ Department of Hygiene, Microbiology and Social Medicine, Medical University Innsbruck, Fritz-Pregl Str. 3, A-6020 Innsbruck, Austria. [email protected]

Abstract

The in vitro activity of posaconazole plus amphotericin B against conidia and hyphae of 30 clinical zygomycetes was investigated. The combination of posaconazole with amphotericin B was found to be significantly more synergistic (40%) against hyphae (P < 0.05) than against conidia (10%). Antagonism was not observed.

MeSH terms

Absidia / drug effects
Amphotericin B / administration & dosage*
Antifungal Agents / administration & dosage*
Cunninghamella / drug effects
Drug Synergism
Humans
Hyphae / drug effects
Microbial Sensitivity Tests
Mucor / drug effects
Mucorales / drug effects*
Mucorales / pathogenicity
Mucorales / ultrastructure
Mucormycosis / drug therapy
Mucormycosis / microbiology
Rhizomucor / drug effects
Rhizopus / drug effects
Spores, Fungal / drug effects
Triazoles / administration & dosage*

Substances

Antifungal Agents
Triazoles
posaconazole
Amphotericin B