Abstract
The purpose of this study was to evaluate the effects of a chitosan membrane coated with polylactic and polyglycolic acid (PLGA) on bone regeneration in a rat calvarial defect. Surgical implantation of chitosan membranes resulted in enhanced local bone formation at both 2 and 8 weeks. In conclusion, the chitosan membrane coated with PLGA had a significant potential to induce bone formation in the rat calvarial defect model. Within the selected PLGA dose range and observation intervals, there appeared to be no meaningful differences in bone formation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bone Regeneration / physiology*
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Bone Substitutes / therapeutic use*
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Chitosan / chemistry
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Chitosan / therapeutic use*
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Coated Materials, Biocompatible / chemistry
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Coated Materials, Biocompatible / therapeutic use
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Lactic Acid / chemistry
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Lactic Acid / therapeutic use*
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Male
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Materials Testing
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Membranes, Artificial
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Polyesters
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Polyglycolic Acid / chemistry
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Polyglycolic Acid / therapeutic use*
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Polylactic Acid-Polyglycolic Acid Copolymer
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Polymers / chemistry
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Polymers / therapeutic use*
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Rats
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Rats, Sprague-Dawley
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Skull / injuries
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Skull / pathology
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Skull / surgery
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Skull Fractures / pathology*
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Skull Fractures / surgery*
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Treatment Outcome
Substances
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Bone Substitutes
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Coated Materials, Biocompatible
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Membranes, Artificial
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Polyesters
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Polymers
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Polylactic Acid-Polyglycolic Acid Copolymer
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Polyglycolic Acid
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Lactic Acid
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poly(lactide)
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Chitosan