Abstract
A new cycloartane, monocarpinine (1), incorporating a fused tetrahydrofuranyl ring, and a cytotoxic tetracyclic lactam, monomarginine (2), were isolated from a stem bark extract of the Malayan species Monocarpia marginalis. The structures of these compounds were determined using NMR and MS analysis. Monomarginine (2) showed appreciable cytotoxicity toward human KB (both drug-sensitive and drug-resistant) and Jurkat cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Annonaceae / chemistry*
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Drug Resistance, Neoplasm / drug effects
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Drug Screening Assays, Antitumor
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Furans / chemistry
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Furans / isolation & purification*
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Furans / pharmacology*
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Humans
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Jurkat Cells
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KB Cells
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Lactams / chemistry
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Lactams / isolation & purification*
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Lactams / pharmacology*
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Malaysia
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plants, Medicinal / chemistry*
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology*
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Vincristine / pharmacology
Substances
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Antineoplastic Agents, Phytogenic
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Furans
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Lactams
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Triterpenes
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monocarpinine
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cycloartane
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Vincristine