Two new spermidine compounds, namely safflospermidine A (1) and safflospermidine B (2), together with two known compounds, N(1),N(5),N(10)-(Z)-tri-p-coumaroylspermidine (3) and N(1),N(5),N(10)-(E)-tri-p-coumaroylspermidine (4), were isolated from the florets of Carthamus tinctorius L. Their structures were elucidated by spectroscopic means.