Finite element modeling of cooled-tip probe radiofrequency ablation processes in liver tissue

Comput Biol Med. 2008 Jun;38(6):694-708. doi: 10.1016/j.compbiomed.2008.03.007. Epub 2008 May 7.

Abstract

Finite element model of radiofrequency ablation (RFA) with cooled-tip probe in liver has been developed by employing COMSOL Multiphysics software. It describes coupled electric, thermal and sodium chloride solution infiltration flow phenomena taking place during ablation processes. Features of hydraulic capacity, saturation of the tissue by infiltration, and dependency of electrical conductivity on the damage integral of the tissue have been supplied to the model. RFA experiments have validated the model. Physical parameters describing hydraulic capacity and hydraulic conductivity in the tissue, as well as, the relation of electrical conductivity against the value of damage integral have been determined.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biophysical Phenomena
  • Biophysics
  • Catheter Ablation / statistics & numerical data*
  • Computer Simulation*
  • Finite Element Analysis*
  • Humans
  • In Vitro Techniques
  • Liver / anatomy & histology
  • Liver / physiology
  • Liver Neoplasms / therapy*
  • Radiofrequency Therapy
  • Swine