Abstract
Cytotoxic necrotizing factor 1 (CNF1) is a well-defined virulence factor of uropathogenic Escherichia coli. We studied the role of CNF1 in uroepithelial cells as well as in children and adults with sporadic and recurrent UTI. Our study suggests that CNF1 may promote bacterial attachment and invasion and can induce an inflammatory response in the urinary tract in vitro but that its role in vivo is possibly minor in comparison with other virulence factors of the uropathogenic E. coli.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Toxins / genetics
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Cells, Cultured
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Epithelial Cells / microbiology
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Escherichia coli / genetics
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Escherichia coli / pathogenicity*
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Escherichia coli Proteins / genetics
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Escherichia coli Proteins / physiology*
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Humans
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Mutation
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Tissue Inhibitor of Metalloproteinase-1 / metabolism
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Urinary Tract / microbiology*
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Urinary Tract Infections / microbiology
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Virulence Factors / genetics
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Virulence Factors / physiology*
Substances
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Bacterial Toxins
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Escherichia coli Proteins
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Tissue Inhibitor of Metalloproteinase-1
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Virulence Factors
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cytotoxic necrotizing factor type 1