9-Thiourea Cinchona alkaloid supported on mesoporous silica as a highly enantioselective, recyclable heterogeneous asymmetric catalyst

Chem Commun (Camb). 2008 May 28:(20):2355-7. doi: 10.1039/b800640g. Epub 2008 Mar 17.

Abstract

A readily recycled and regenerated heterogeneous catalyst of 9-thiourea epi-quinine supported on mesoporous silica exhibits enhanced enantioselectivity (up to 99.2%) in the asymmetric Friedel-Crafts reaction of imines with indoles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Cinchona Alkaloids / chemistry*
  • Imines / chemistry
  • Indoles / chemistry
  • Quinine / analogs & derivatives*
  • Silicon Dioxide / chemistry*
  • Stereoisomerism
  • Thiourea / analogs & derivatives*
  • Thiourea / chemistry

Substances

  • Cinchona Alkaloids
  • Imines
  • Indoles
  • Silicon Dioxide
  • Quinine
  • Thiourea