Abstract
The use of radiopharmaceuticals for the diagnosis of infection is increasing due to their ability to distinguish between septic and aseptic inflammation. The aim of this study was to analyze the intracellular accumulation of technetium-99m-ciprofloxacin in strains of Staphylococcus aureus and Pseudomonas aeruginosa harboring an overexpression of NorA and MexAB-OprM, respectively.
MeSH terms
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Bacterial Outer Membrane Proteins / genetics
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Bacterial Outer Membrane Proteins / metabolism
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism
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Ciprofloxacin / analogs & derivatives*
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Ciprofloxacin / pharmacokinetics
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Gene Expression
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Genes, Bacterial
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Humans
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Membrane Transport Proteins / genetics
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Membrane Transport Proteins / metabolism
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Multidrug Resistance-Associated Proteins / genetics
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Multidrug Resistance-Associated Proteins / metabolism
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Organotechnetium Compounds / pharmacokinetics*
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Pseudomonas Infections / diagnostic imaging
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Pseudomonas Infections / microbiology
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Pseudomonas aeruginosa / genetics
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Pseudomonas aeruginosa / metabolism*
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Radionuclide Imaging
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Radiopharmaceuticals / pharmacokinetics*
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Staphylococcal Infections / diagnostic imaging
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Staphylococcal Infections / microbiology
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Staphylococcus aureus / genetics
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Staphylococcus aureus / metabolism*
Substances
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Bacterial Outer Membrane Proteins
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Bacterial Proteins
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Membrane Transport Proteins
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MexA protein, Pseudomonas aeruginosa
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MexB protein, Pseudomonas aeruginosa
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Multidrug Resistance-Associated Proteins
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OprM protein, Pseudomonas aeruginosa
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Organotechnetium Compounds
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Radiopharmaceuticals
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Technetium Tc 99m ciprofloxacin
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NorA protein, Staphylococcus
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Ciprofloxacin