Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments

P J Peters; J J Neefjes; V Oorschot; H L Ploegh; H J Geuze

doi:10.1038/349669a0

Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments

Nature. 1991 Feb 21;349(6311):669-76. doi: 10.1038/349669a0.

Authors

P J Peters¹, J J Neefjes, V Oorschot, H L Ploegh, H J Geuze

Affiliation

¹ Laboratory of Cell Biology, Medical School, University of Utrecht, The Netherlands.

PMID: 1847504
DOI: 10.1038/349669a0

Abstract

Traffic of MHC molecules dictates the source of peptides that are presented to T cells. The intracellular distribution of MHC class I and class II molecules reflects the dichotomy in presentation of antigen from endogenous and exogenous origin, respectively. In human B lymphoblastoid cells, class I molecules are present in compartments constituting the biosynthetic pathway, whereas class II molecules enter structures related to lysosomes during their biosynthesis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antigens, CD*
B-Lymphocytes / metabolism*
Biological Transport
Cell Line, Transformed
Endocytosis / immunology
Golgi Apparatus / metabolism
HLA-D Antigens / biosynthesis
HLA-D Antigens / metabolism*
Herpesvirus 4, Human
Histocompatibility Antigens Class I / metabolism*
Humans
Lysosomal Membrane Proteins
Lysosomes / chemistry
Lysosomes / metabolism
Membrane Glycoproteins / analysis
Membrane Proteins / analysis
Organelles / chemistry
Platelet Membrane Glycoproteins*
Receptor, IGF Type 2
Receptors, Cell Surface / analysis
Tetraspanin 30
beta-N-Acetylhexosaminidases / analysis

Substances

Antigens, CD
CD63 protein, human
HLA-D Antigens
Histocompatibility Antigens Class I
Lysosomal Membrane Proteins
Membrane Glycoproteins
Membrane Proteins
Platelet Membrane Glycoproteins
Receptor, IGF Type 2
Receptors, Cell Surface
Tetraspanin 30
beta-N-Acetylhexosaminidases