High yielding alkylations of unactivated sp3 and sp2 centres with alkyl-9-BBN reagents using an NHC-based catalyst: Pd-PEPPSI-IPrf

Cory Valente; Sylvia Baglione; David Candito; Christopher J O'Brien; Michael G Organ

doi:10.1039/b715081d

High yielding alkylations of unactivated sp3 and sp2 centres with alkyl-9-BBN reagents using an NHC-based catalyst: Pd-PEPPSI-IPrf

Chem Commun (Camb). 2008 Feb 14:(6):735-7. doi: 10.1039/b715081d.

Authors

Cory Valente¹, Sylvia Baglione, David Candito, Christopher J O'Brien, Michael G Organ

Affiliation

¹ Department of Chemistry, York University, 4700 Keele Street, Toronto, Ontario, M3J 1P3, Canada.

PMID: 18478707
DOI: 10.1039/b715081d

Abstract

High yielding, room temperature cross couplings of unactivated alkyl bromides and aryl bromides/chlorides with alkyl-9-BBN reagents has been achieved using an NHC-based catalyst (Pd-PEPPSI-IPr) via a general, functional-group tolerant and easily implemented protocol.