Abstract
Bioassay-guided fractionation of the MeOH extract of Suaeda glauca yielded four phenolic compounds, methyl 3,5-di-O-caffeoyl quinate (1) and 3,5-di-O-caffeoyl quinic acid (2), isorhamnetin 3-O-beta-D-galactoside (3), and quercetin 3-O-beta-D-galactoside (4). Compounds 1 and 2 were hepatoprotective against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells with the EC(50) values of 72.7+/-6.2 and 117.2+/-10.5 microM, respectively. Silybin as a positive control showed an EC(50) value of 82.4+/-4.1 microM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Carcinoma, Hepatocellular
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Cell Line, Tumor
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Chenopodiaceae*
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Chlorogenic Acid / analogs & derivatives*
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Chlorogenic Acid / chemistry
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Chlorogenic Acid / isolation & purification
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Chlorogenic Acid / pharmacology
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification
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Drugs, Chinese Herbal / pharmacology
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Humans
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Liver Neoplasms
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Protective Agents / chemistry
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Protective Agents / pharmacology*
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Tacrine / toxicity
Substances
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3,5-dicaffeoylquinic acid methyl ester
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Drugs, Chinese Herbal
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Protective Agents
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Chlorogenic Acid
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Tacrine
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3,5-dicaffeoylquinic acid