Abstract
Two new indolocarbazole alkaloids, 7-oxo-3,8,9-trihydroxystaurosporine (1) and 7-oxo-8,9-dihydroxy-4'-N-demethylstaurosporine (2), were isolated from samples of the marine ascidian Cystodytes solitus. Their structures were determined by a combination of spectroscopic techniques, including (+)-HRMALDITOFMS and 1D and 2D NMR spectroscopy, and comparison with published data for related structures. Both compounds displayed strong cytotoxicity against three human tumor cell lines.
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology*
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology*
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Drug Screening Assays, Antitumor
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Humans
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Marine Biology
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Staurosporine / analogs & derivatives*
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Staurosporine / chemistry
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Staurosporine / isolation & purification*
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Staurosporine / pharmacology*
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Tanzania
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Urochordata / chemistry*
Substances
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7-oxo-3,8,9-trihydroxystaurosporine
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7-oxo-8,9-dihydroxy-4'-N-demethylstaurosporine
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Alkaloids
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Antineoplastic Agents
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Staurosporine