Objectives: Vesicoureteral reflux is a pathologic entity with different forms of therapeutic management, one of which is endoscopic injection of various materials. We show some histological changes produced by these materials in the bladder wall.
Methods: We study three samples of intravesical ureter from three children suffering vesicoureteral reflux. The ureters were obtained during ureteral reimplantation surgery.
Results: We show the changes found with various materials under study (polytetrafluorethylene, polydimethylsiloxane, hyaluronic acid and dextranomer copolimer) observing less conjunctive tissue with the two latter and with the more encapsulated hyaluronic acid - dextranomer copolimer.
Conclusions: Migrations and granulomas are described with various materials and we ascertained the presence of foreign body reaction and fibrosis within the bladder wall. More studies in human beings are required to determine the best product for endoscopic injection.