An association between invasive breast cancer and familial idiopathic hyperparathyroidism: a case series and review of the literature

Sumanta Kumar Pal; Kathleen Blazer; Jeffrey Weitzel; George Somlo

doi:10.1007/s10549-008-0056-8

An association between invasive breast cancer and familial idiopathic hyperparathyroidism: a case series and review of the literature

Breast Cancer Res Treat. 2009 May;115(1):1-5. doi: 10.1007/s10549-008-0056-8. Epub 2008 May 26.

Authors

Sumanta Kumar Pal¹, Kathleen Blazer, Jeffrey Weitzel, George Somlo

Affiliation

¹ Department of Medical Oncology & Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.

PMID: 18500673
DOI: 10.1007/s10549-008-0056-8

Abstract

The possibility of an association between primary hyperparathyroidism and breast cancer has been postulated. We report here a sibship with three premenopausal breast cancers and hyperparathyroidism, and no detectable BRCA or MEN1 gene mutations. We explore genetic and molecular rationales for an association between these metabolic and neoplastic processes.

Publication types

Review

MeSH terms

Adult
Breast Neoplasms / complications*
Breast Neoplasms / epidemiology
Breast Neoplasms / genetics
Family Health
Female
Genes, BRCA1
Genetic Predisposition to Disease
Humans
Hyperparathyroidism / complications*
Hyperparathyroidism / epidemiology
Hyperparathyroidism / genetics
Middle Aged
Multiple Endocrine Neoplasia / genetics
Mutation
Neoplasm Invasiveness
Pedigree
Proto-Oncogene Proteins / genetics

Substances

MEN1 protein, human
Proto-Oncogene Proteins