Abstract
The twin-Cx(9)C motif protein Pet191 is essential for cytochrome c oxidase maturation. The motif Cys residues are functionally important and appear to be present in disulfide linkages within a large oligomeric complex associated with the mitochondrial inner membrane. The import of Pet191 differs from that of other twin-Cx(9)C motif class of proteins in being independent of the Mia40 pathway.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Amino Acid Motifs
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Electron Transport Complex IV / biosynthesis
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Electron Transport Complex IV / metabolism*
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Energy Metabolism / genetics
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Gene Expression Regulation, Fungal / genetics
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Membrane Proteins / chemistry
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Membrane Proteins / genetics
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Membrane Proteins / metabolism*
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Mitochondrial Membranes / metabolism
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Mitochondrial Membranes / ultrastructure
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Saccharomyces cerevisiae / genetics
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Saccharomyces cerevisiae / metabolism*
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Saccharomyces cerevisiae Proteins / chemistry
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Saccharomyces cerevisiae Proteins / genetics
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Saccharomyces cerevisiae Proteins / metabolism*
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Signal Transduction / genetics
Substances
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Membrane Proteins
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Pet191 protein, S cerevisiae
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Saccharomyces cerevisiae Proteins
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Electron Transport Complex IV