Abstract
In the course of our screening program for new bio-active compounds, a novel triazolopyrimidine antibiotic, essramycin (1), was obtained from the culture broth of the marine Streptomyces sp., isolate Merv8102. Structure 1 was established by intensive NMR studies and by mass spectra. The compound is antibacterially active with MIC of 2 to 8 microg/ml against Gram-positive and Gram-negative bacteria, while it showed no antifungal activity. The fermentation and isolation, as well as the structure elucidation and biological activity of 1 are described.
MeSH terms
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Chemical Phenomena
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Chemistry, Physical
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Chromatography, Thin Layer
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Fermentation
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Microbial Sensitivity Tests
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Molecular Conformation
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Molecular Weight
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Pyrimidines / isolation & purification
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Pyrimidines / pharmacology*
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Pyrimidinones
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Streptomyces / metabolism*
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Triazoles / isolation & purification
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Triazoles / pharmacology*
Substances
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Anti-Bacterial Agents
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Indicators and Reagents
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Pyrimidines
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Pyrimidinones
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Triazoles
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essramycin