Abstract
A family of three novel aminofuran antibiotics named as proximicins was isolated from the marine Verrucosispora strain MG-37. Proximicin A was detected in parallel in the marine abyssomicin producer "Verrucosispora maris" AB-18-032. The characteristic structural element of proximicins is 4-amino-furan-2-carboxylic acid, a hitherto unknown gamma-amino acid. Proximicins show a weak antibacterial activity but a strong cytostatic effect to various human tumor cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Actinobacteria / chemistry
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Actinobacteria / classification
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Actinobacteria / metabolism*
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Anti-Bacterial Agents / biosynthesis
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Antibiotics, Antineoplastic / biosynthesis
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Antibiotics, Antineoplastic / isolation & purification
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Antibiotics, Antineoplastic / pharmacology*
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Bacteria / drug effects
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Cell Line, Tumor
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Chemical Phenomena
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Chemistry, Physical
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Chromatography, High Pressure Liquid
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Fermentation
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Humans
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Microbial Sensitivity Tests
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Netropsin / analogs & derivatives*
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Netropsin / biosynthesis
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Netropsin / isolation & purification
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Netropsin / pharmacology
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Spectrophotometry, Ultraviolet
Substances
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Anti-Bacterial Agents
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Antibiotics, Antineoplastic
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proximicin A
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proximicin B
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proximicin C
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Netropsin