Abstract
There is a need for diverse molecular libraries for phenotype-selective and high-throughput screening. To make marine natural products (MNPs) more amenable to newer screening paradigms and shorten discovery time lines, we have created an MNP library characterized online using MS. To test the potential of the library, we screened a subset of the library in a phenotype-selective screen to identify compounds that inhibited the growth of BRCA2-deficient cells.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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BRCA2 Protein / deficiency*
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Biological Products / chemistry
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Biological Products / pharmacology*
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Combinatorial Chemistry Techniques
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Cricetinae
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Cricetulus
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DNA / metabolism
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Dose-Response Relationship, Drug
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Drug Design*
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Fiji
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Molecular Structure
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Porifera / chemistry*
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Small Molecule Libraries / chemistry
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Small Molecule Libraries / pharmacology*
Substances
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BRCA2 Protein
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Biological Products
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Small Molecule Libraries
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DNA