Abstract
A new phloroglucinol, hyperielliptone HA (1/1a), a new spirophloroglucinol possessing an unprecedented skeleton, hyperielliptone HB (2/2a), and two new xanthonolignoids, hyperielliptones HC (3) and HD (4), were isolated from the heartwood of Hypericum geminiflorum. Compounds 1/1a and 2/2a were obtained as tautomeric pairs. The structures and relative configurations of these compounds were elucidated by spectroscopic methods. In biological testing, compound 2/ 2a revealed significant inhibition of oxidative DNA damage and an inhibitory effect on xanthine oxidase.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Algorithms
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Antioxidants* / chemistry
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Antioxidants* / isolation & purification
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Antioxidants* / pharmacology
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DNA Damage / drug effects
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Free Radical Scavengers* / chemistry
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Free Radical Scavengers* / isolation & purification
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Free Radical Scavengers* / pharmacology
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Hypericum / chemistry*
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Molecular Structure
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Phloroglucinol* / analogs & derivatives
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Phloroglucinol* / chemistry
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Phloroglucinol* / isolation & purification
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Phloroglucinol* / pharmacology
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Plants, Medicinal / chemistry*
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Stereoisomerism
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Taiwan
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Xanthine Oxidase / antagonists & inhibitors*
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Xanthine Oxidase / metabolism
Substances
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Antioxidants
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Free Radical Scavengers
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hyperielliptone HA
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Phloroglucinol
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Xanthine Oxidase