A common polymorphism is associated with body mass index in Uyghur population

Jun Zhang; Rong Lin; Fen Wang; Ming Lu; Ren-yong Lin; Shi-zhen Wang; Hao Wen; Li Jin; Xiao-feng Wang

doi:10.1016/j.diabres.2008.03.022

A common polymorphism is associated with body mass index in Uyghur population

Diabetes Res Clin Pract. 2008 Aug;81(2):e11-3. doi: 10.1016/j.diabres.2008.03.022. Epub 2008 Jun 2.

Authors

Jun Zhang¹, Rong Lin, Fen Wang, Ming Lu, Ren-yong Lin, Shi-zhen Wang, Hao Wen, Li Jin, Xiao-feng Wang

Affiliation

¹ MOE Key Laboratory of Contemporary Anthropology and Center for Evolutionary Biology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.

PMID: 18514965
DOI: 10.1016/j.diabres.2008.03.022

Abstract

We aimed at observing the association of a common genetic variant near the INSIG2 gene (rs7655505) with body mass index (BMI) related obesity in a population-based association study in Uyghur population. We observed a significant association of rs7566605 polymorphism with BMI related obesity in Uyghurs with an odds ratio of 1.47 (95% CI 1.11-1.95, P=0.006) under a dominant model (CC+GC versus GG). The mean BMI of rs7566605 CC+GC was 0.59kg/m(2) higher than for GG genotype (P=0.024), regardless of sex and age.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Body Mass Index*
China
Gene Frequency
Genotype
Humans
Intracellular Signaling Peptides and Proteins / genetics*
Membrane Proteins / genetics*
Obesity / genetics
Odds Ratio
Polymorphism, Genetic*
Regression Analysis

Substances

INSIG2 protein, human
Intracellular Signaling Peptides and Proteins
Membrane Proteins