Serotonergic influences on sexual function are poorly understood. SSRI have been associated not only with impairment of sexual function but with restoration of sexual potency. We report a case of recurrent priapism that was treated with Fluoxetine and low dose Perphenazine. During 20 months of follow up, his priapism has been in remission but it recurred very dramatically twice after drugs were tapered off. This case report proves that sexual side effects of Fluoxetine and low dose of Perphenazine may be more variable than previously thought.