Abstract
Retinoic acid, vitamin D3, and dexamethasone are known inducers of myeloid leukemic cell differentiation. Recent evidence indicates that these drugs mediate their biological effects through binding to a nuclear receptor which belongs to the steroid/thyroid hormone receptor superfamily. This paper shows that the ligands of the other receptors of this family, estrogens, progesterone, androgens and thyroid hormone, do not induce leukemic cell differentiation. However, thyroid hormone potentiates, by one order of magnitude, the dose-response effect of retinoic acid in HL-60 cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Differentiation / drug effects
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Cholecalciferol / pharmacology
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Dose-Response Relationship, Drug
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Drug Synergism
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Granulocytes / cytology
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Granulocytes / drug effects*
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Humans
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Leukemia, Experimental / drug therapy
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Leukemia, Experimental / metabolism
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Leukemia, Experimental / pathology*
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Leukemia, Myeloid / drug therapy
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Leukemia, Myeloid / metabolism
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Leukemia, Myeloid / pathology*
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Oxygen / metabolism
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Stimulation, Chemical
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Thyroid Hormones / pharmacology*
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Tretinoin / pharmacology*
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Triiodothyronine / pharmacology
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Tumor Cells, Cultured
Substances
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Thyroid Hormones
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Triiodothyronine
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Cholecalciferol
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Tretinoin
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Oxygen