Abstract
Corollosporine isolated from the marine fungus Corollospora maritima and N-analogous corollosporines are antimicrobial substances. Owing to the basic structure of the N-analogous corollosporines, they have become an attractive target for laccase-catalyzed derivatisation. In this regard we report on the straightforward laccase-catalyzed amination of dihydroxylated arenes with N-analogous corollosporines. In biological assays the obtained amination products are more active than the parent compounds.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amination
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / pharmacology*
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Antifungal Agents / chemical synthesis
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Antifungal Agents / pharmacology
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Bacteria / drug effects
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Candida / drug effects
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Catalysis
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Chromatography, High Pressure Liquid
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Laccase / metabolism*
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Methicillin Resistance
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Microbial Sensitivity Tests
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Phthalic Anhydrides / chemical synthesis*
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Phthalic Anhydrides / pharmacology*
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Spectrometry, Mass, Electrospray Ionization
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Staphylococcus aureus / drug effects
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Phthalic Anhydrides
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corollosporine
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Laccase