Abstract
Two new triterpenoid saponins, zygophylosides O (1) and P (2), have been isolated from the barks of Zygophyllum fabago L. Their structures were elucidated as 3beta-[(2-O-sulfo-beta-D-xylopyranosyl)oxy]urs-12-ene-27,28-dioic acid and 3beta-[(2-O-sulfo-beta-D-xylopyranosyl)oxy]urs-12-ene-27,28-dioic acid 28-beta-D-glucopyranoside, respectively, by spectral and chemical evidence. Compound 1 showed weaker Nitric Oxide (NO) inhibitory activity.
MeSH terms
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Animals
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Cell Line
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Hydrolysis
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Macrophages / metabolism
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Magnetic Resonance Spectroscopy
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Mice
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Molecular Conformation
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Nitric Oxide / antagonists & inhibitors
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Nitric Oxide / biosynthesis
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Plant Bark / chemistry
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Plant Extracts / chemistry
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Saponins / isolation & purification*
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Spectrometry, Mass, Electrospray Ionization
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Spectrophotometry, Infrared
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Tetrazolium Salts
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Thiazoles
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Triterpenes / isolation & purification*
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Zygophyllum / chemistry*
Substances
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Plant Extracts
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Saponins
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Tetrazolium Salts
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Thiazoles
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Triterpenes
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zygophyloside O
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zygophyloside P
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Nitric Oxide
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thiazolyl blue