We provide a theoretical description of the spatio-temporal dynamics of sequential filamentation in noble gases that can lead to pulse compression down to nearly single-cycle pulses. We show that the strong pulse compression occurs as a result of serially-generated on-axis filaments and spectral filtering of an extensive blue-shifted compressible spectra. We show that the dynamics of this sequential filamentation can be readily tuned by varying the gas pressure and can be scaled to various pulse energies.