Nickel-catalyzed carboxylation of organozinc reagents with CO2

Org Lett. 2008 Jul 3;10(13):2681-3. doi: 10.1021/ol800764u. Epub 2008 Jun 4.

Abstract

An efficient nickel catalyst system for the carboxylation of organozinc reagents with CO(2) under very mild conditions has been developed. The catalyst system complements the conventional methods and enables the direct synthesis of various saturated carboxylic acid derivatives from the corresponding alkylzinc reagents and CO(2).