Abstract
The intracerebroventricular injection of the cholecystokinin-A receptor antagonist L-364,718, at the doses of 0.5, 5, 10 or 20 micrograms/mouse, while having no effect on pain threshold (hot plate, 51 degrees C), antagonized the analgesic activity of morphine (10 mg/kg i.p.). This effect was obtained with a dose of 10 micrograms/mouse and was associated with a reduction of brainstem opiate-binding sites.
MeSH terms
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Analgesia*
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Animals
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Benzodiazepinones / metabolism
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Benzodiazepinones / pharmacology*
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Brain Stem / metabolism
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Cholecystokinin / antagonists & inhibitors*
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Devazepide
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Female
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Male
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Mice
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Morphine*
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Pain / drug therapy
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Pain / metabolism
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Pain / physiopathology*
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Receptors, Cholecystokinin / antagonists & inhibitors
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Sensory Thresholds
Substances
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Benzodiazepinones
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Receptors, Cholecystokinin
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Morphine
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Cholecystokinin
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Devazepide